Exercise
Effects of hydrogen rich water on prolonged intermittent exercise
…improved performance in intermittent cycling exercises when the duration was longer than 30 min (anaerobic).
…prevented an elevation of blood lactate and decreased muscle fatigue during heavy exercise.
Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries
The addition of hydrogen to traditional treatment protocols is potentially effective in the treatment of soft tissue injuries in male professional athletes.
H2-water, compared to placebo water, enhanced endurance and relieved psychometric fatigue as measured by maximal oxygen consumption and Borg’s scale and visual analogue scales.
Drinking H2-rich water before and after strenuous exercise reduced the exercise-induced increase in ROS levels.
Short-term H2 inhalation improves running performance and torso strength in healthy adults
…an increase in peak running velocity up to 4.2% in a running time-to-exhaustion test after seven days of inhaling 4% H2 for 20 min each day.
Metabolic Issues
…decreases serum TC/HDL-C levels, and reduces oxidative stress in patients with potential metabolic syndrome.
…decreases serum TC and LDL-C and apo B levels, improves HDL function, and reduces oxidative stress in patients with potential metabolic syndrome.
Supplementation with hydrogen-rich water may have a beneficial role in prevention of [Type 2 diabetes] and insulin resistance.
…significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis as compared to placebo. Furthermore, H2 tended to promote a mild reduction in body mass index and waist-to-hip ratio.
…significantly reduced body fat percentage and arm fat index compared to placebo administration, respectively. This was accompanied by a significant drop in serum triglycerides after H2 intervention comparing to placebo.
Hydrogen rich water for 8 weeks resulted in a 39% increase in antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease in thiobarbituric acid reactive substances (TBARS) in urine. 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol.
Cardiac Issues
Numerous animal studies have found that hydrogen therapy improves left ventricular function, infarct size, oxidative stress, apoptosis and autophagy in cardiac disease.¹²³⁴⁵⁶⁷⁸
…improved the recovery of [left ventricular] function during reoxygenation after anoxia in the isolated perfused heart.
…may aid in maintaining functional vasculature via neutralization of detrimental ROS to preserve NO bioavailability, suppression of the inflammatory events that cause atherosclerosis.
…increases antioxidant capacity thereby reducing inflammatory responses and apoptosis in healthy adults.
Respiratory Issues
Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients
…positive therapeutic effect on airway inflammation in patients with asthma and COPD.
Compared with oxygen, the inhalation of hydrogen/oxygen mixture resulted in a more significant improvement of AECOPD [acute exacerbation of chronic obstructive pulmonary disease] symptoms.
Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis
H2-O2 may reduce the inspiratory effort in patients with acute severe tracheal stenosis and can be used for this purpose safely.
Infection
Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice
Seven-day survival rate in septic mice was significantly improved in the H2 inhalation group compared with that in the control group.
Hydrogen gas alleviates sepsis-induced brain injury in mice by improving mitochondrial biogenesis through the activation of PGC-1α.
Hydrogen-rich water attenuates experimental periodontitis in a rat model
Consuming hydrogen-rich water might be beneficial in suppressing periodontitis progression by decreasing gingival oxidative stress.
Molecular Hydrogen Therapy—A Review on Clinical Studies and Outcomes
H2 inhalation can be beneficial for COVID-19 patients for at least three different reasons; (i) a reduction of ROS levels, (ii) reduced airflow resistance for eased respiratory conditions and (iii) a reduction in inflammatory responses.
…significant improvements in 6-min walking test distance, forced vital capacity and expiratory volume.
Nervous System
Secondary outcomes suggest that H2 inhalation may increase 90-day survival without neurological deficits.
Administration of hydroxyl radical scavengers in acute stage of brainstem infarction improved MRI indices against the natural course. The effects were more obvious and significant in the EH group. These findings may imply the need for more frequent daily administration of hydroxyl scavenger.
Hydrogen-rich saline prevented Abeta-induced neuroinflammation and oxidative stress, which may contribute to the improvement of memory dysfunction.
…low concentration of H2 in drinking water can reduce oxidative stress in the brain. Thus, drinking H2-containing water may be useful in daily life to prevent or minimize the risk of life style-related oxidative stress and neurodegeneration.
Molecular hydrogen prevented both the development and progression of the nigrostrital degeneration.
Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease
UPDRS scores began significantly decreasing from the first week, and this improvement persisted until the end of therapy. Moreover, no adverse event was recorded.
Autoimmune Disease
Drop infusion of H2 safely and effectively reduced [rheumatoid arthritis] disease activity.
The hydroxyl radical scavenger H2 effectively reduces oxidative stress in patients with this condition. The symptoms of [rheumatoid arthritis] were significantly improved with high H2 water.
The survival rate at 4 years in the response group is significantly higher. Hydrogen showed great efficacy and long-term administration of hydrogen was not associated with significant toxic effects.
Liver Disease
Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease.
…inhalation of hydrogen/oxygen improved serum lipid and liver enzymes. Significantly improved liver fat content detected by ultrasound and CT scans after hydrogen/oxygen inhalation was observed in moderate–severe cases.
Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial
…decreased weight (≈1 kg) and body mass index in the HRW group. HRW was well-tolerated, with no significant changes in liver enzymes and a trend of improved lipid profile and reduced lactate dehydrogenase levels. HRW tended to non-significantly decrease levels of nuclear factor kappa B, heat shock protein 70 and matrix metalloproteinase-9.
Cancer
The probability and degree of chemotherapy-induced liver damage in the hydrogen-rich water group were lower compared with those in the placebo group…Hydrogen has good distribution characteristics, and it can penetrate biomembranes and diffuse into the cytoplasm, mitochondrion and nucleus. its rapid gas diffusion properties are very effective in reducing the toxicity of free radicals in cells.
…reverses imbalances toward PD‑1+ CD8+ T cells to provide an improved prognosis.
H2 monotherapy could prolong the PFS of patients with advanced NSCLC, suggesting that H2 could inhibit the growth of lung cancer cells independently.
…improved [quality of life] and reduced oxidative markers in patients receiving radiotherapy for liver tumors.
Hydrogen has potential for improving the quality of life of patients during chemotherapy by efficiently mitigating the side effects of cisplatin.
Hydrogen protects auditory hair cells from cisplatin-induced free radicals
Hydrogen can protect auditory tissues against cisplatin toxicity, thus providing an additional strategy to protect against drug-induced inner ear damage.
…enhances the overall survival time of nivolumab-treated lung cancer patients. The MST of the patients treated with nivolumab and hydrogen gas (28 months) is about three times longer than that of those treated with nivolumab only (9 months).
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